Which of the following describes the relationship between ventilation and pressure changes in the chest?

The relationship between ventilation and pressure changes in the chest is primarily governed by the principles of physics, specifically Boyle's law, which states that in a closed system, pressure and volume are inversely related. During ventilation, the diaphragm and intercostal muscles are activated, which leads to changes in the volume of the thoracic cavity. As the volume increases during inhalation, the pressure inside the chest cavity decreases relative to atmospheric pressure, causing air to flow into the lungs. Conversely, during exhalation, the volume inside the chest decreases, increasing the pressure and forcing air out of the lungs.

This process clearly illustrates that ventilation is not independent of pressure changes, nor does it occur only during exhalation. While muscle contraction is a crucial aspect of the process, ventilation is not solely reliant on active muscle contraction, as passive exhalation can also occur. Thus, understanding that ventilation is primarily caused by changes in pressure helps to clarify how the mechanics of breathing operate effectively.