What condition is signaled by both an increase in metabolic demand and low oxygen content in blood?

The condition indicated by both an increase in metabolic demand and low oxygen content in the blood is hypoxemia. Hypoxemia refers specifically to low levels of oxygen in the bloodstream, which can result from various factors, including respiratory issues, decreased oxygen availability in the environment, or conditions that impair oxygenation in the lungs.

When the body's metabolic demand goes up, for instance during intense physical activity or illness, the tissues require more oxygen to function effectively. If there is a low oxygen content in the blood during such times, the body's ability to deliver sufficient oxygen to meet these increased demands can be compromised, leading to symptoms like fatigue, confusion, and even organ dysfunction.

The other choices provided pertain to different physiological conditions. Hypoglycemia involves low blood sugar levels, which is not directly related to oxygen levels in the blood. Hyperthermia refers to an elevated body temperature, whereas hyperglycemia signifies high blood sugar levels. None of these conditions directly combine increased metabolic demand with inadequate oxygen supply as hypoxemia does.